Efficacy and Mechanism Evaluation

Volume 9 (2022)

9 issues

Extended Research Article

Molecular selection of therapy in metastatic colorectal cancer: the FOCUS4 molecularly stratified RCT

Louise C Brown
,
David Fisher
,
Richard Adams
,
Jenny Seligmann
,
Matthew Seymour
,
Richard Kaplan
et al.
  • Journal:
    Efficacy and Mechanism Evaluation Volume: 9, Issue: 9
  • Published:
    21 December 2022

Extended Research Article

Leucine and perindopril to improve physical performance in people over 70 years with sarcopenia: the LACE factorial RCT

Miles D Witham
,
Simon Adamson
,
Alison Avenell
,
Margaret M Band
,
Tufail Bashir
,
Peter T Donnan
et al.
  • Journal:
    Efficacy and Mechanism Evaluation Volume: 9, Issue: 8
  • Published:
    30 August 2022

Extended Research Article

Rituximab versus tocilizumab and B-cell status in TNF-alpha inadequate-responder rheumatoid arthritis patients:the R4-RA RCT

Frances Humby
,
Patrick Durez
,
Maya H Buch
,
Myles J Lewis
,
Michele Bombardieri
,
Christopher John
et al.
  • Journal:
    Efficacy and Mechanism Evaluation Volume: 9, Issue: 7
  • Published:
    22 August 2022

Extended Research Article

OROS-methylphenidate to reduce ADHD symptoms in male prisoners aged 16-25 years: a RCT

Philip Asherson
,
Lena Johansson
,
Rachel Holland
,
Megan Bedding
,
Andrew Forrester
,
Laura Giannulli
et al.
  • Journal:
    Efficacy and Mechanism Evaluation Volume: 9, Issue: 6
  • Published:
    5 July 2022

Extended Research Article

Omalizumab for severe atopic dermatitis in 4- to 19-year-olds: the ADAPT RCT

Susan MH Chan
,
Suzie Cro
,
Victoria Cornelius
,
Rahi Jahan
,
Suzana Radulovic
,
Gideon Lack
  • Journal:
    Efficacy and Mechanism Evaluation Volume: 9, Issue: 5
  • Published:
    6 June 2022

Extended Research Article

Treatment guided by fractional exhaled nitric oxide in addition to standard care in 6- to 15-year-olds with asthma: the RAACENO RCT

Steve Turner
,
Seonaidh Cotton
,
Jessica Wood
,
Victoria Bell
,
Edwin-Amalraj Raja
,
Neil W Scott
et al.
  • Journal:
    Efficacy and Mechanism Evaluation Volume: 9, Issue: 4
  • Published:
    6 June 2022

Extended Research Article

An adapted social communication intervention at home and education to promote social communication change in children with severe autism: the PACT-G RCT

Jonathan Green
,
Kathy Leadbitter
,
Ceri Ellis
,
Lauren Taylor
,
Heather L Moore
,
Sophie Carruthers
et al.
  • Journal:
    Efficacy and Mechanism Evaluation Volume: 9, Issue: 3
  • Published:
    17 May 2022

Extended Research Article

The interleukin 1 receptor antagonist anakinra to reduce disease severity of palmoplantar pustulosis in adults: APRICOT RCT and PLUM mechanistic study

Suzie Cro
,
Victoria Cornelius
,
Francesca Capon
,
Jonathan Barker
,
David Burden
,
Christopher Griffiths
et al.
  • Journal:
    Efficacy and Mechanism Evaluation Volume: 9, Issue: 2
  • Published:
    30 March 2022

Extended Research Article

Monoclonal antibody BTT1023 targeting vascular adhesion protein 1 for treating primary sclerosing cholangitis: BUTEO single-arm Phase II trial

Katherine Arndtz
,
Yung-Yi Chen
,
Anna Rowe
,
Victoria Homer
,
Amanda Kirkham
,
Jessica Douglas-Pugh
et al.
  • Journal:
    Efficacy and Mechanism Evaluation Volume: 9, Issue: 1
  • Published:
    10 March 2022