Efficacy and Mechanism Evaluation - Volume 8

Extended Research Article

A 10-year impact assessment of the Efficacy and Mechanism Evaluation (EME) programme: an independent mixed-method evaluation study

Maike C Rentel

,

Kelly Simpson

,

Anoushka Davé

,

Scott Carter

,

Margaret Blake

,

Jan Franke

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 8, Issue: 20
Published:

19 November 2021

Extended Research Article

Losartan to slow the progression of mild-to-moderate Alzheimer's disease through angiotensin targeting: the RADAR RCT

Patrick G Kehoe

,

Nicholas Turner

,

Beth Howden

,

Lina Jarutyt

,

Shona L Clegg

,

Ian B Malone

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 8, Issue: 19
Published:

3 November 2021

Extended Research Article

Thoracoscopic surgical ablation versus catheter ablation as first-line treatment for long-standing persistent atrial fibrillation: the CASA-AF RCT

Shouvik Haldar

,

Habib R Khan

,

Vennela Boyalla

,

Ines Kralj-Hans

,

Simon Jones

,

Joanne Lord

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 8, Issue: 18
Published:

1 November 2021

Extended Research Article

Variable short duration treatment versus standard treatment, with and without adjunctive ribavirin, for chronic hepatitis C: the STOP-HCV-1 non-inferiority, factorial RCT

Graham S Cooke

,

Sarah Pett

,

Leanne McCabe

,

Christopher Jones

,

Richard Gilson

,

Sumita Verma

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 8, Issue: 17
Published:

28 October 2021

Extended Research Article

Continuous glucose monitoring in extremely preterm infants in intensive care: the REACT RCT and pilot study of 'closed-loop' technology

Kathryn Beardsall

,

Lynn Thomson

,

Catherine Guy

,

Simon Bond

,

Annabel Allison

,

Beatrice Pantaleo

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 8, Issue: 16
Published:

28 October 2021

Extended Research Article

Epithelium-off corneal cross-linking surgery compared with standard care in 10- to 16-year-olds with progressive keratoconus: the KERALINK RCT

Daniel FP Larkin

,

Kashfia Chowdhury

,

Caroline J Doré

,

Catey Bunce

,

Jennifer M Burr

,

Emilia Caverly

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 8, Issue: 15
Published:

12 October 2021

Extended Research Article

Lactoferrin impact on gut microbiota in preterm infants with late-onset sepsis or necrotising enterocolitis: the MAGPIE mechanisms of action study

Nicholas Embleton

,

Janet Berrington

,

Stephen Cummings

,

Jon Dorling

,

Andrew Ewer

,

Alessandra Frau

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 8, Issue: 14
Published:

28 September 2021

Extended Research Article

Paclitaxel-assisted balloon angioplasty of venous stenosis in haemodialysis access: PAVE RCT

Narayan Karunanithy

,

Emily J Robinson

,

Francis Calder

,

Anthony Dorling

,

Janet L Peacock

,

Yanzhong Wang

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 8, Issue: 13
Published:

27 September 2021

Extended Research Article

Planned delivery to improve postpartum cardiac function in women with preterm pre-eclampsia: the PHOEBE mechanisms of action study within the PHOENIX RCT

Fergus P McCarthy

,

Jamie O’Driscoll

,

Paul Seed

,

Anna Brockbank

,

Alice Cox

,

Carolyn Gill

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 8, Issue: 12
Published:

21 September 2021

Extended Research Article

Digitally supported CBT to reduce paranoia and improve reasoning for people with schizophrenia-spectrum psychosis: the SlowMo RCT

Philippa Garety

,

Thomas Ward

,

Richard Emsley

,

Kathryn Greenwood

,

Daniel Freeman

,

David Fowler

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 8, Issue: 11
Published:

12 August 2021

Extended Research Article

Defining phenotypes and treatment effect heterogeneity to inform acute respiratory distress syndrome and sepsis trials: secondary analyses of three RCTs

Manu Shankar-Hari

,

Shalini Santhakumaran

,

A Toby Prevost

,

Josie K Ward

,

Timothy Marshall

,

Claire Bradley

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 8, Issue: 10
Published:

3 August 2021

Extended Research Article

Co-trimoxazole to reduce mortality, transplant, or unplanned hospitalisation in people with moderate to very severe idiopathic pulmonary fibrosis: the EME-TIPAC RCT

Andrew M Wilson

,

Allan B Clark

,

Anthony Cahn

,

Edwin R Chilvers

,

William Fraser

,

Matthew Hammond

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 8, Issue: 9
Published:

30 July 2021

Extended Research Article

Emergent aneurysm treatment compared with treatment on neurological improvement in patients with ruptured poor-grade aneurysmal subarachnoid haemorrhage: the TOPSAT2 RCT

Philip White

,

Barbara Gregson

,

Elaine McColl

,

Paul Brennan

,

Alison Steel

,

Philippa Watts

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 8, Issue: 8
Published:

21 July 2021

Extended Research Article

Probiotics to reduce antibiotic administration in care home residents aged 65 years and older: the PRINCESS RCT

Christopher C Butler

,

Eleri Owen-Jones

,

Mandy Lau

,

David Gillespie

,

Mark Lown

,

Philip C Calder

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 8, Issue: 7
Published:

4 May 2021

Extended Research Article

Selenium supplementation to improve bone health in postmenopausal women: the SeMS three-arm RCT

Jennifer S Walsh

,

Richard Jacques

,

Lutz Schomburg

,

Tom Hill

,

John Mathers

,

Graham Williams

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 8, Issue: 6
Published:

27 April 2021

Extended Research Article

New technologies for diagnosing active TB: the VANTDET diagnostic accuracy study

Alice Halliday

,

Pooja Jain

,

Long Hoang

,

Robert Parker

,

Mica Tolosa-Wright

,

Tereza Masonou

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 8, Issue: 5
Published:

13 April 2021

Extended Research Article

Using cardiovascular magnetic resonance to define mechanisms of comorbidity and to measure the effect of biological therapy: the CADERA observational study

Sven Plein

,

Bara Erhayiem

,

Graham Fent

,

Jacqueline Andrews

,

John Greenwood

,

Paul Baxter

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 8, Issue: 4
Published:

24 March 2021

Extended Research Article

Long limb compared with standard limb Roux-en-Y gastric bypass for type 2 diabetes and obesity: the LONG LIMB RCT

Alexander Dimitri Miras

,

Anna Kamocka

,

Tricia Tan

,

Belén Pérez-Pevida

,

Harvinder Chahal

,

Krishna Moorthy

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 8, Issue: 3
Published:

17 February 2021

Extended Research Article

Eplerenone versus placebo for chronic central serous chorioretinopathy: the VICI RCT

Andrew Lotery

,

Sobha Sivaprasad

,

Abby O’Connell

,

Rosie A Harris

,

Lucy Culliford

,

Angela Cree

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 8, Issue: 2
Published:

18 January 2021

Extended Research Article

Enhanced neoplasia detection in chronic ulcerative colitis: the ENDCaP-C diagnostic accuracy study

Ashish Awasthi

,

Jamie Barbour

,

Andrew Beggs

,

Pradeep Bhandari

,

Daniel Blakeway

,

Matthew Brookes

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 8, Issue: 1
Published:

11 January 2021

Volume 8 (2021)

20 issues

A 10-year impact assessment of the Efficacy and Mechanism Evaluation (EME) programme: an independent mixed-method evaluation study

Losartan to slow the progression of mild-to-moderate Alzheimer's disease through angiotensin targeting: the RADAR RCT

Thoracoscopic surgical ablation versus catheter ablation as first-line treatment for long-standing persistent atrial fibrillation: the CASA-AF RCT

Variable short duration treatment versus standard treatment, with and without adjunctive ribavirin, for chronic hepatitis C: the STOP-HCV-1 non-inferiority, factorial RCT

Continuous glucose monitoring in extremely preterm infants in intensive care: the REACT RCT and pilot study of 'closed-loop' technology

Epithelium-off corneal cross-linking surgery compared with standard care in 10- to 16-year-olds with progressive keratoconus: the KERALINK RCT

Lactoferrin impact on gut microbiota in preterm infants with late-onset sepsis or necrotising enterocolitis: the MAGPIE mechanisms of action study

Paclitaxel-assisted balloon angioplasty of venous stenosis in haemodialysis access: PAVE RCT

Planned delivery to improve postpartum cardiac function in women with preterm pre-eclampsia: the PHOEBE mechanisms of action study within the PHOENIX RCT

Digitally supported CBT to reduce paranoia and improve reasoning for people with schizophrenia-spectrum psychosis: the SlowMo RCT

Defining phenotypes and treatment effect heterogeneity to inform acute respiratory distress syndrome and sepsis trials: secondary analyses of three RCTs

Co-trimoxazole to reduce mortality, transplant, or unplanned hospitalisation in people with moderate to very severe idiopathic pulmonary fibrosis: the EME-TIPAC RCT

Emergent aneurysm treatment compared with treatment on neurological improvement in patients with ruptured poor-grade aneurysmal subarachnoid haemorrhage: the TOPSAT2 RCT

Probiotics to reduce antibiotic administration in care home residents aged 65 years and older: the PRINCESS RCT

Selenium supplementation to improve bone health in postmenopausal women: the SeMS three-arm RCT

New technologies for diagnosing active TB: the VANTDET diagnostic accuracy study

Using cardiovascular magnetic resonance to define mechanisms of comorbidity and to measure the effect of biological therapy: the CADERA observational study

Long limb compared with standard limb Roux-en-Y gastric bypass for type 2 diabetes and obesity: the LONG LIMB RCT

Eplerenone versus placebo for chronic central serous chorioretinopathy: the VICI RCT

Enhanced neoplasia detection in chronic ulcerative colitis: the ENDCaP-C diagnostic accuracy study

Volume 8 (2021)

20 issues

A 10-year impact assessment of the Efficacy and Mechanism Evaluation (EME) programme: an independent mixed-method evaluation study

Losartan to slow the progression of mild-to-moderate Alzheimer's disease through angiotensin targeting: the RADAR RCT

Thoracoscopic surgical ablation versus catheter ablation as first-line treatment for long-standing persistent atrial fibrillation: the CASA-AF RCT

Variable short duration treatment versus standard treatment, with and without adjunctive ribavirin, for chronic hepatitis C: the STOP-HCV-1 non-inferiority, factorial RCT

Continuous glucose monitoring in extremely preterm infants in intensive care: the REACT RCT and pilot study of 'closed-loop' technology

Epithelium-off corneal cross-linking surgery compared with standard care in 10- to 16-year-olds with progressive keratoconus: the KERALINK RCT

Lactoferrin impact on gut microbiota in preterm infants with late-onset sepsis or necrotising enterocolitis: the MAGPIE mechanisms of action study

Paclitaxel-assisted balloon angioplasty of venous stenosis in haemodialysis access: PAVE RCT

Planned delivery to improve postpartum cardiac function in women with preterm pre-eclampsia: the PHOEBE mechanisms of action study within the PHOENIX RCT

Digitally supported CBT to reduce paranoia and improve reasoning for people with schizophrenia-spectrum psychosis: the SlowMo RCT

Defining phenotypes and treatment effect heterogeneity to inform acute respiratory distress syndrome and sepsis trials: secondary analyses of three RCTs

Co-trimoxazole to reduce mortality, transplant, or unplanned hospitalisation in people with moderate to very severe idiopathic pulmonary fibrosis: the EME-TIPAC RCT

Emergent aneurysm treatment compared with treatment on neurological improvement in patients with ruptured poor-grade aneurysmal subarachnoid haemorrhage: the TOPSAT2 RCT

Probiotics to reduce antibiotic administration in care home residents aged 65 years and older: the PRINCESS RCT

Selenium supplementation to improve bone health in postmenopausal women: the SeMS three-arm RCT

New technologies for diagnosing active TB: the VANTDET diagnostic accuracy study

Using cardiovascular magnetic resonance to define mechanisms of comorbidity and to measure the effect of biological therapy: the CADERA observational study

Long limb compared with standard limb Roux-en-Y gastric bypass for type 2 diabetes and obesity: the LONG LIMB RCT

Eplerenone versus placebo for chronic central serous chorioretinopathy: the VICI RCT

Enhanced neoplasia detection in chronic ulcerative colitis: the ENDCaP-C diagnostic accuracy study

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