Efficacy and Mechanism Evaluation

Volume 3 (2016)

10 issues

Extended Research Article

A randomised placebo-controlled trial investigating efficacy and mechanisms of low-dose intradermal allergen immunotherapy in treatment of seasonal allergic rhinitis

Anna Slovick
,
Abdel Douiri
,
Rachel Muir
,
Andrea Guerra
,
Konstantinos Tsioulos
,
Evie Haye
et al.
  • Journal:
    Efficacy and Mechanism Evaluation Volume: 3, Issue: 10
  • Published:
    9 December 2016

Extended Research Article

The REFLO-STEMI (REperfusion Facilitated by LOcal adjunctive therapy in ST-Elevation Myocardial Infarction) trial: a randomised controlled trial comparing intracoronary administration of adenosine or sodium nitroprusside with control for attenuation of microvascular obstruction during primary percutaneous coronary intervention

Sheraz A Nazir
,
Jamal N Khan
,
Islam Z Mahmoud
,
John P Greenwood
,
Daniel J Blackman
,
Vijay Kunadian
et al.
  • Journal:
    Efficacy and Mechanism Evaluation Volume: 3, Issue: 9
  • Published:
    8 December 2016

Extended Research Article

A randomised, double-blind, placebo-controlled study to evaluate the efficacy of oral azithromycin as a supplement to standard care for adult patients with acute exacerbations of asthma (the AZALEA trial)

Sebastian L Johnston
,
Matyas Szigeti
,
Mary Cross
,
Christopher Brightling
,
Rekha Chaudhuri
,
Timothy Harrison
et al.
  • Journal:
    Efficacy and Mechanism Evaluation Volume: 3, Issue: 8
  • Published:
    31 October 2016

Extended Research Article

Does metformin reduce excess birthweight in offspring of obese pregnant women? A randomised controlled trial of efficacy, exploration of mechanisms and evaluation of other pregnancy complications

Carolyn A Chiswick
,
Rebecca M Reynolds
,
Fiona C Denison
,
Amanda J Drake
,
Shareen Forbes
,
David E Newby
et al.
  • Journal:
    Efficacy and Mechanism Evaluation Volume: 3, Issue: 7
  • Published:
    31 August 2016

Extended Research Article

Next Generation intraoperative Lymph node staging for Stratified colon cancer surgery (GLiSten): a multicentre, multinational feasibility study of fluorescence in predicting lymph node-positive disease

Helen Andrew
,
Gemma Gossedge
,
Julie Croft
,
Neil Corrigan
,
Julia M Brown
,
Nicholas West
et al.
  • Journal:
    Efficacy and Mechanism Evaluation Volume: 3, Issue: 6
  • Published:
    17 August 2016

Extended Research Article

A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis

Eric WFW Alton
,
David K Armstrong
,
Deborah Ashby
,
Katie J Bayfield
,
Diana Bilton
,
Emily V Bloomfield
et al.
  • Journal:
    Efficacy and Mechanism Evaluation Volume: 3, Issue: 5
  • Published:
    18 July 2016

Extended Research Article

Effect of Remote Ischaemic preconditioning on Clinical outcomes in patients undergoing Coronary Artery bypass graft surgery (ERICCA study): a multicentre double-blind randomised controlled clinical trial

Derek J Hausenloy
,
Luciano Candilio
,
Richard Evans
,
Cono Ariti
,
David P Jenkins
,
Shyamsunder Kolvekar
et al.
  • Journal:
    Efficacy and Mechanism Evaluation Volume: 3, Issue: 4
  • Published:
    23 June 2016

Extended Research Article

Wilms' tumour antigen 1 Immunity via DNA fusion gene vaccination in haematological malignancies by intramuscular injection followed by intramuscular electroporation: a Phase II non-randomised clinical trial (WIN)

Christian Ottensmeier
,
Megan Bowers
,
Debbie Hamid
,
Tom Maishman
,
Scott Regan
,
Wendy Wood
et al.
  • Journal:
    Efficacy and Mechanism Evaluation Volume: 3, Issue: 3
  • Published:
    13 April 2016

Extended Research Article

Nutritional Evaluation and Optimisation in Neonates (NEON) trial of amino acid regimen and intravenous lipid composition in preterm parenteral nutrition: a randomised double-blind controlled trial

Sabita Uthaya
,
Xinxue Liu
,
Daphne Babalis
,
Caroline Dore
,
Jane Warwick
,
Jimmy Bell
et al.
  • Journal:
    Efficacy and Mechanism Evaluation Volume: 3, Issue: 2
  • Published:
    24 March 2016

Extended Research Article

The randomised Complete versus Lesion-only PRimary percutaneous coronary Intervention Trial: Cardiovascular Magnetic Resonance imaging substudy (CvLPRIT-CMR)

Gerry P McCann
,
Jamal N Khan
,
John P Greenwood
,
Sheraz A Nazir
,
Miles Dalby
,
Nick Curzen
et al.
  • Journal:
    Efficacy and Mechanism Evaluation Volume: 3, Issue: 1
  • Published:
    27 January 2016