Efficacy and Mechanism Evaluation - Volume 11

Extended Research Article

Clinical effectiveness of subsensory sacral neuromodulation in adults with faecal incontinence: the SUBSoNIC crossover RCT and mechanistic study

Paul F Vollebregt

,

Yan Li Goh

,

Claire L Chan

,

Thomas Dudding

,

Paul Furlong

,

Shaheen Hamdy

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 11, Issue: 19
Published:

21 November 2024

Extended Research Article

The efficacy of sildenafil therapy in dismal prognosis early-onset intrauterine growth restriction: the STRIDER RCT

Andrew Sharp

,

Christine Cornforth

,

Richard Jackson

,

Jane Harrold

,

Mark A Turner

,

Louise Kenny

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 11, Issue: 18
Published:

31 October 2024

Extended Research Article

Infliximab versus alpha interferon in the treatment of Behçet's disease: the BIO BEHÇET'S RCT

Robert J Moots

,

Farida Fortune

,

Richard Jackson

,

Tony Thornburn

,

Ann W Morgan

,

Dan Carr

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 11, Issue: 17
Published:

31 October 2024

Extended Research Article

Efficacy and safety of ketogenic diet in infants with epilepsy: KIWE RCT

Natasha E Schoeler

,

Louise Marston

,

Laura Lyons

,

Sally Halsall

,

Ruchika Jain

,

Siobhan Titre-Johnson

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 11, Issue: 16
Published:

9 October 2024

Extended Research Article

Development and evaluation of machine learning methods in whole-body magnetic resonance imaging with diffusion weighted imaging for staging of patients with cancer: the MALIBO diagnostic test accuracy study

Andrea Rockall

,

Xingfeng Li

,

Nicholas Johnson

,

Ioannis Lavdas

,

Shalini Santhakumaran

,

A Toby Prevost

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 11, Issue: 15
Published:

9 October 2024

Extended Research Article

Determining the optimal route of faecal microbiota transplant in patients with ulcerative colitis: the STOP-Colitis pilot RCT

Mohammed N Quraishi

,

Catherine A Moakes

,

Mehmet Yalchin

,

Jonathan Segal

,

Natalie J Ives

,

Laura Magill

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 11, Issue: 14
Published:

29 August 2024

Extended Research Article

Bezafibrate as treatment in males for Barth syndrome: CARDIOMAN, a double-blind, placebo-controlled crossover RCT

Guido Pieles

,

Colin Steward

,

Lucy Dabner

,

Laura Collet

,

Lucy Culliford

,

Karen Sheehan

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 11, Issue: 13
Published:

22 August 2024

Extended Research Article

High-sensitivity cardiac troponin I-guided combination angiotensin receptor blockade and beta blocker therapy to prevent anthracycline cardiotoxicity: the Cardiac CARE RCT

Peter Henriksen

,

Morag MacLean

,

Marek Atter

,

Steff Lewis

,

Aryelly Rodriguez

Journal:

Efficacy and Mechanism Evaluation Volume: 11, Issue: 12
Published:

15 August 2024

Extended Research Article

Efficacy and safety of eculizumab in children with Shiga-toxin-producing Escherichia coli haemolytic uraemic syndrome: the ECUSTEC RCT

Natalie Ives

,

Rebecca Woolley

,

Moin A Saleem

,

Catherine A Moakes

,

Aoife Waters

,

Rodney D Gilbert

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 11, Issue: 11
Published:

25 July 2024

Extended Research Article

Prophylactic zoledronic acid therapy to prevent or modify Paget's disease of bone progression in adults with SQSTM1 mutations: the ZiPP RCT

Jonathan Phillips

,

Deepak Subedi

,

Steff C Lewis

,

Catriona Keerie

,

Stuart H Ralston

Journal:

Efficacy and Mechanism Evaluation Volume: 11, Issue: 10
Published:

27 June 2024

Extended Research Article

Gene therapy for choroideremia using an adeno-associated viral vector encoding Rab escort protein 1: the REGENERATE open-label trial

Jasmina Cehajic-Kapetanovic

,

Marco P Bellini

,

Laura J Taylor

,

Imran H Yusuf

,

Taha Soomro

,

Lyndon da Cruz

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 11, Issue: 9
Published:

21 May 2024

Extended Research Article

The effect of closed-loop glucose control on C-peptide secretion in youth with newly diagnosed type 1 diabetes: the CLOuD RCT

Charlotte K Boughton

,

Janet M Allen

,

Julia Ware

,

Malgorzata E Wilinska

,

Sara Hartnell

,

Ajay Thankamony

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 11, Issue: 8
Published:

21 May 2024

Extended Research Article

Automated closed-loop insulin delivery for the management of type 1 diabetes during pregnancy: the AiDAPT RCT

Tara TM Lee

,

Corinne Collett

,

Simon Bergford

,

Sara Hartnell

,

Eleanor M Scott

,

Robert S Lindsay

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 11, Issue: 7
Published:

30 April 2024

Extended Research Article

Intravenous immunoglobulin treatment for encephalitis in children aged 6 months to 16 years: the IgNiTE RCT

Mildred A Iro

,

Manish Sadarangani

,

Michael Absoud

,

Liberty Cantrell

,

Wui K Chong

,

Christopher Clark

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 11, Issue: 6
Published:

9 April 2024

Extended Research Article

Withdrawal of renin-angiotensin system inhibitors' effect on estimated glomerular filtration rate in adults with advanced kidney disease: the STOP-ACEi RCT

Sunil Bhandari

,

Samir Mehta

,

Arif Khwaja

,

John Cleland

,

Natalie Ives

,

Elizabeth Brettell

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 11, Issue: 5
Published:

27 March 2024

Extended Research Article

Rituximab compared to intravenous cyclophosphamide in adults with connective tissue disease-associated interstitial lung disease: the RECITAL RCT

Toby M Maher

,

Veronica A Tudor

,

Peter Saunders

,

Fernando Zanghelini

,

Carlota Grossi Sampedro

,

Georgios Xydopoulos

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 11, Issue: 4
Published:

27 February 2024

Extended Research Article

Autologous stem cell transplantation with low-dose cyclophosphamide to improve mucosal healing in adults with refractory Crohn's disease: the ASTIClite RCT

James O Lindsay

,

Daniel Hind

,

Lizzie Swaby

,

Hannah Berntsson

,

Mike Bradburn

,

Uday Bannur C

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 11, Issue: 3
Published:

20 February 2024

Extended Research Article

Resuscitation with pre-hospital blood products in adults with trauma-related haemorrhagic shock: the RePHILL RCT

Nicholas Crombie

,

Heidi A Doughty

,

Jonathan RB Bishop

,

Amisha Desai

,

Emily F Dixon

,

James M Hancox

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 11, Issue: 2
Published:

9 January 2024

Extended Research Article

Evaluation of efficacy, outcomes and safety of infant haemodialysis and ultrafiltration in clinical use: I-KID a stepped wedge cluster RCT

Heather Lambert

,

Shaun Hiu

,

Malcolm Coulthard

,

John N S Matthews

,

Ruth Wood

,

Jean Crosier

et al.

Journal:

Efficacy and Mechanism Evaluation Volume: 11, Issue: 1
Published:

9 January 2024

Volume 11 (2024)

19 issues

Clinical effectiveness of subsensory sacral neuromodulation in adults with faecal incontinence: the SUBSoNIC crossover RCT and mechanistic study

The efficacy of sildenafil therapy in dismal prognosis early-onset intrauterine growth restriction: the STRIDER RCT

Infliximab versus alpha interferon in the treatment of Behçet's disease: the BIO BEHÇET'S RCT

Efficacy and safety of ketogenic diet in infants with epilepsy: KIWE RCT

Development and evaluation of machine learning methods in whole-body magnetic resonance imaging with diffusion weighted imaging for staging of patients with cancer: the MALIBO diagnostic test accuracy study

Determining the optimal route of faecal microbiota transplant in patients with ulcerative colitis: the STOP-Colitis pilot RCT

Bezafibrate as treatment in males for Barth syndrome: CARDIOMAN, a double-blind, placebo-controlled crossover RCT

High-sensitivity cardiac troponin I-guided combination angiotensin receptor blockade and beta blocker therapy to prevent anthracycline cardiotoxicity: the Cardiac CARE RCT

Efficacy and safety of eculizumab in children with Shiga-toxin-producing Escherichia coli haemolytic uraemic syndrome: the ECUSTEC RCT

Prophylactic zoledronic acid therapy to prevent or modify Paget's disease of bone progression in adults with SQSTM1 mutations: the ZiPP RCT

Gene therapy for choroideremia using an adeno-associated viral vector encoding Rab escort protein 1: the REGENERATE open-label trial

The effect of closed-loop glucose control on C-peptide secretion in youth with newly diagnosed type 1 diabetes: the CLOuD RCT

Automated closed-loop insulin delivery for the management of type 1 diabetes during pregnancy: the AiDAPT RCT

Intravenous immunoglobulin treatment for encephalitis in children aged 6 months to 16 years: the IgNiTE RCT

Withdrawal of renin-angiotensin system inhibitors' effect on estimated glomerular filtration rate in adults with advanced kidney disease: the STOP-ACEi RCT

Rituximab compared to intravenous cyclophosphamide in adults with connective tissue disease-associated interstitial lung disease: the RECITAL RCT

Autologous stem cell transplantation with low-dose cyclophosphamide to improve mucosal healing in adults with refractory Crohn's disease: the ASTIClite RCT

Resuscitation with pre-hospital blood products in adults with trauma-related haemorrhagic shock: the RePHILL RCT

Evaluation of efficacy, outcomes and safety of infant haemodialysis and ultrafiltration in clinical use: I-KID a stepped wedge cluster RCT

Volume 11 (2024)

19 issues

Clinical effectiveness of subsensory sacral neuromodulation in adults with faecal incontinence: the SUBSoNIC crossover RCT and mechanistic study

The efficacy of sildenafil therapy in dismal prognosis early-onset intrauterine growth restriction: the STRIDER RCT

Infliximab versus alpha interferon in the treatment of Behçet's disease: the BIO BEHÇET'S RCT

Efficacy and safety of ketogenic diet in infants with epilepsy: KIWE RCT

Development and evaluation of machine learning methods in whole-body magnetic resonance imaging with diffusion weighted imaging for staging of patients with cancer: the MALIBO diagnostic test accuracy study

Determining the optimal route of faecal microbiota transplant in patients with ulcerative colitis: the STOP-Colitis pilot RCT

Bezafibrate as treatment in males for Barth syndrome: CARDIOMAN, a double-blind, placebo-controlled crossover RCT

High-sensitivity cardiac troponin I-guided combination angiotensin receptor blockade and beta blocker therapy to prevent anthracycline cardiotoxicity: the Cardiac CARE RCT

Efficacy and safety of eculizumab in children with Shiga-toxin-producing Escherichia coli haemolytic uraemic syndrome: the ECUSTEC RCT

Prophylactic zoledronic acid therapy to prevent or modify Paget's disease of bone progression in adults with SQSTM1 mutations: the ZiPP RCT

Gene therapy for choroideremia using an adeno-associated viral vector encoding Rab escort protein 1: the REGENERATE open-label trial

The effect of closed-loop glucose control on C-peptide secretion in youth with newly diagnosed type 1 diabetes: the CLOuD RCT

Automated closed-loop insulin delivery for the management of type 1 diabetes during pregnancy: the AiDAPT RCT

Intravenous immunoglobulin treatment for encephalitis in children aged 6 months to 16 years: the IgNiTE RCT

Withdrawal of renin-angiotensin system inhibitors' effect on estimated glomerular filtration rate in adults with advanced kidney disease: the STOP-ACEi RCT

Rituximab compared to intravenous cyclophosphamide in adults with connective tissue disease-associated interstitial lung disease: the RECITAL RCT

Autologous stem cell transplantation with low-dose cyclophosphamide to improve mucosal healing in adults with refractory Crohn's disease: the ASTIClite RCT

Resuscitation with pre-hospital blood products in adults with trauma-related haemorrhagic shock: the RePHILL RCT

Evaluation of efficacy, outcomes and safety of infant haemodialysis and ultrafiltration in clinical use: I-KID a stepped wedge cluster RCT

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