Health Technology Assessment

Volume 19 (2015)

101 issues

Extended Research Article

The clinical effectiveness and cost-effectiveness of STeroids or Pentoxifylline for Alcoholic Hepatitis (STOPAH): a 2x2 factorial, randomised controlled trial

Mark Thursz
,
Ewan Forrest
,
Paul Roderick
,
Christopher Day
,
Andrew Austin
,
John O’Grady
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 102
  • Published:
    21 December 2015

Extended Research Article

A randomised controlled trial of computerised cognitive behaviour therapy for the treatment of depression in primary care: The Randomised Evaluation of the Effectiveness and Acceptability of Computerised Therapy (REEACT) trial

Elizabeth Littlewood
,
Ana Duarte
,
Catherine Hewitt
,
Sarah Knowles
,
Stephen Palmer
,
Simon Walker
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 101
  • Published:
    21 December 2015

Extended Research Article

Optimal strategies for monitoring lipid levels in patients at risk or with cardiovascular disease: best marker for monitoring and cost-effectiveness of different monitoring frequencies

Rafael Perera
,
Emily McFadden
,
Julie McLellan
,
Tom Lung
,
Philip Clarke
,
Teresa Pérez
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 100
  • Published:
    21 December 2015

Extended Research Article

Behaviour change techniques: the development and evaluation of a taxonomic method for reporting and describing behaviour change interventions (a suite of five studies involving consensus methods, randomised controlled trials and analysis of qualitative data)

Susan Michie
,
Caroline E Wood
,
Marie Johnston
,
Charles Abraham
,
Jill J Francis
,
Wendy Hardeman
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 99
  • Published:
    30 November 2015

Extended Research Article

Graduated compression stockings for the prevention of deep vein thrombosis in postoperative surgical patients; a systematic review and economic model with a value of information analysis

Ros Wade
,
Eleftherios Sideris
,
Fiona Paton
,
Stephen Rice
,
Stephen Palmer
,
Dave Fox
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 98
  • Published:
    30 November 2015

Extended Research Article

Protocolised Management In Sepsis (ProMISe): a multicentre, randomised controlled trial of the clinical and cost-effectiveness of early protocolised resuscitation for emerging septic shock

Paul R Mouncey
,
Tiffany M Osborn
,
G Sarah Power
,
David A Harrison
,
M Zia Sadique
,
Richard D Grieve
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 97
  • Published:
    24 November 2015

Extended Research Article

Procalcitonin testing to guide antibiotic therapy for the treatment of sepsis in intensive care settings and for suspected bacterial infection in emergency department settings: a systematic review and cost-effectiveness analysis

Marie Westwood
,
Bram Ramaekers
,
Penny Whiting
,
Florian Tomini
,
Manuela Joore
,
Nigel Armstrong
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 96
  • Published:
    16 November 2015

Extended Research Article

Evaluating Long-term Outcomes of NHS Stop Smoking Services (ELONS): a prospective cohort study

Fiona Dobbie
,
Rosemary Hiscock
,
Jo Leonardi-Bee
,
Susan Murray
,
Lion Shahab
,
Paul Aveyard
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 95
  • Published:
    16 November 2015

Extended Research Article

Effectiveness and acceptability of parental financial incentives and quasi-mandatory schemes for increasing uptake of vaccinations in preschool children: systematic review, qualitative study, and discrete choice experiment

Jean Adams
,
Belinda Bateman
,
Frauke Becker
,
Tricia Cresswell
,
Darren Flynn
,
Rebekah McNaughton
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 94
  • Published:
    10 November 2015

Extended Research Article

Evaluation and validation of social and psychological markers in randomised trials of complex interventions in mental health: a methodological research programme

Graham Dunn
,
Richard Emsley
,
Hanhua Liu
,
Sabine Landau
,
Jonathan Green
,
Ian White
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 93
  • Published:
    10 November 2015

Extended Research Article

The clinical and cost-effectiveness of open mesh repairs in adults presenting with a clinically diagnosed unilateral, primary inguinal hernia who are operated in an elective setting: systematic review and economic evaluation

Pawana Sharma
,
Dwayne Boyers
,
Neil Scott
,
Rodolfo Hernández
,
Cynthia Fraser
,
Moira Cruickshank
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 92
  • Published:
    10 November 2015

Extended Research Article

Fluorouracil plasma monitoring: systematic review and economic evaluation of the My5-FU assay for guiding dose adjustment in patients receiving fluorouracil chemotherapy by continuous infusion

Karoline Freeman
,
Martin Connock
,
Ewen Cummins
,
Tara Gurung
,
Sian Taylor-Phillips
,
Rachel Court
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 91
  • Published:
    9 November 2015

Extended Research Article

Collagenase clostridium histolyticum for the treatment of Dupuytren's contracture: systematic review and economic evaluation

Miriam Brazzelli
,
Moira Cruickshank
,
Emma Tassie
,
Paul McNamee
,
Clare Robertson
,
Andrew Elders
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 90
  • Published:
    2 November 2015

Extended Research Article

Development of processes allowing near real-time refinement and validation of triage tools during the early stage of an outbreak in readiness for surge: the FLU-CATs Study

Sudhir Venkatesan
,
Puja R Myles
,
Gerard McCann
,
Antonis A Kousoulis
,
Maimoona Hashmi
,
Rabah Belatri
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 89
  • Published:
    2 November 2015

Extended Research Article

A randomised controlled trial of the clinical effectiveness and cost-effectiveness of the levonorgestrel-releasing intrauterine system in primary care against standard treatment for menorrhagia: the ECLIPSE trial

Janesh K Gupta
,
Jane P Daniels
,
Lee J Middleton
,
Helen M Pattison
,
Gail Prileszky
,
Tracy E Roberts
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 88
  • Published:
    28 October 2015

Extended Research Article

The clinical effectiveness and cost-effectiveness of the PROGENSA® prostate cancer antigen 3 assay and the Prostate Health Index in the diagnosis of prostate cancer: a systematic review and economic evaluation

Amanda Nicholson
,
James Mahon
,
Angela Boland
,
Sophie Beale
,
Kerry Dwan
,
Nigel Fleeman
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 87
  • Published:
    28 October 2015

Extended Research Article

Educational interventions to improve quality of life in people with chronic inflammatory skin diseases: systematic reviews of clinical effectiveness and cost-effectiveness

Karen Pickett
,
Emma Loveman
,
Neelam Kalita
,
Geoff K Frampton
,
Jeremy Jones
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 86
  • Published:
    27 October 2015

Extended Research Article

Developing and piloting a peer mentoring intervention to reduce teenage pregnancy in looked-after children and care leavers: an exploratory randomised controlled trial

Gillian Mezey
,
Deborah Meyer
,
Fiona Robinson
,
Chris Bonell
,
Rona Campbell
,
Steve Gillard
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 85
  • Published:
    26 October 2015

Extended Research Article

The London Exercise And Pregnant smokers (LEAP) trial: a randomised controlled trial of physical activity for smoking cessation in pregnancy with an economic evaluation

Michael Ussher
,
Sarah Lewis
,
Paul Aveyard
,
Isaac Manyonda
,
Robert West
,
Beth Lewis
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 84
  • Published:
    22 October 2015

Extended Research Article

A feasibility study to inform the design of a randomised controlled trial to identify the most clinically effective and cost-effective length of Anticoagulation with Low-molecular-weight heparin In the treatment of Cancer-Associated Thrombosis (ALICAT)

Simon I Noble
,
Annmarie Nelson
,
David Fitzmaurice
,
Marie-Jet Bekkers
,
Jessica Baillie
,
Stephanie Sivell
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 83
  • Published:
    22 October 2015

Extended Research Article

Measurement of exhaled nitric oxide concentration in asthma: a systematic review and economic evaluation of NIOX MINO, NIOX VERO and Nobreath

Sue E Harnan
,
Paul Tappenden
,
Munira Essat
,
Tim Gomersall
,
Jon Minton
,
Ruth Wong
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 82
  • Published:
    21 October 2015

Extended Research Article

The cost-effectiveness of domiciliary non-invasive ventilation in patients with end-stage chronic obstructive pulmonary disease: a systematic review and economic evaluation

Janine Dretzke
,
Deirdre Blissett
,
Chirag Dave
,
Rahul Mukherjee
,
Malcolm Price
,
Sue Bayliss
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 81
  • Published:
    19 October 2015

Extended Research Article

Clinical effectiveness and cost-effectiveness of open and arthroscopic rotator cuff repair [the UK Rotator Cuff Surgery (UKUFF) randomised trial]

Andrew J Carr
,
Cushla D Cooper
,
Marion K Campbell
,
Jonathan L Rees
,
Jane Moser
,
David J Beard
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 80
  • Published:
    14 October 2015

Extended Research Article

Early estimation of pandemic influenza Antiviral and Vaccine Effectiveness (EAVE): use of a unique community and laboratory national data-linked cohort study

Colin R Simpson
,
Nazir Lone
,
Jim McMenamin
,
Rory Gunson
,
Chris Robertson
,
Lewis D Ritchie
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 79
  • Published:
    12 October 2015

Extended Research Article

A randomised controlled trial to assess the clinical effectiveness and cost-effectiveness of alternative treatments to Inhibit VEGF in Age-related choroidal Neovascularisation (IVAN)

Usha Chakravarthy
,
Simon P Harding
,
Chris A Rogers
,
Susan Downes
,
Andrew J Lotery
,
Helen A Dakin
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 78
  • Published:
    7 October 2015

Extended Research Article

The Clots in Legs Or sTockings after Stroke (CLOTS) 3 trial: a randomised controlled trial to determine whether or not intermittent pneumatic compression reduces the risk of post-stroke deep vein thrombosis and to estimate its cost-effectiveness

Martin Dennis
,
Peter Sandercock
,
Catriona Graham
,
John Forbes
,
on behalf of the CLOTS (Clots in Legs Or sTockings after Stroke) Trials Collaboration
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 76
  • Published:
    30 September 2015

Extended Research Article

Does home oxygen therapy (HOT) in addition to standard care reduce disease severity and improve symptoms in people with chronic heart failure? A randomised trial of home oxygen therapy for patients with chronic heart failure

Andrew L Clark
,
Miriam Johnson
,
Caroline Fairhurst
,
David Torgerson
,
Sarah Cockayne
,
Sara Rodgers
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 75
  • Published:
    23 September 2015

Extended Research Article

Development of a cost-effectiveness model for optimisation of the screening interval in diabetic retinopathy screening

Peter H Scanlon
,
Stephen J Aldington
,
Jose Leal
,
Ramon Luengo-Fernandez
,
Jason Oke
,
Sobha Sivaprasad
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 74
  • Published:
    18 September 2015

Extended Research Article

The effectiveness and cost-effectiveness of mindfulness-based cognitive therapy compared with maintenance antidepressant treatment in the prevention of depressive relapse/recurrence: results of a randomised controlled trial (the PREVENT study)

Willem Kuyken
,
Rachel Hayes
,
Barbara Barrett
,
Richard Byng
,
Tim Dalgleish
,
David Kessler
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 73
  • Published:
    18 September 2015

Extended Research Article

An open randomised study of autoinflation in 4- to 11-year-old school children with otitis media with effusion in primary care

Ian Williamson
,
Jane Vennik
,
Anthony Harnden
,
Merryn Voysey
,
Rafael Perera
,
Maria Breen
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 72
  • Published:
    18 September 2015

Extended Research Article

Bronchiolitis of Infancy Discharge Study (BIDS): a multicentre, parallel group, double-blind, randomised controlled, equivalence trial with economic evaluation

Steve Cunningham
,
Aryelly Rodriguez
,
Kathleen A Boyd
,
Emma McIntosh
,
Steff C Lewis
,
on behalf of the BIDS Collaborators Group
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 71
  • Published:
    15 September 2015

Extended Research Article

Surgical Trial In Traumatic intraCerebral Haemorrhage (STITCH): a randomised controlled trial of Early Surgery compared with Initial Conservative Treatment

Barbara A Gregson
,
Elise N Rowan
,
Richard Francis
,
Paul McNamee
,
Dwayne Boyers
,
Patrick Mitchell
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 70
  • Published:
    8 September 2015

Extended Research Article

The INTRABEAM® Photon Radiotherapy System for the adjuvant treatment of early breast cancer: a systematic review and economic evaluation

Jo Picot
,
Vicky Copley
,
Jill L Colquitt
,
Neelam Kalita
,
Debbie Hartwell
,
Jackie Bryant
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 69
  • Published:
    1 September 2015

Extended Research Article

The management of Otitis Media with Effusion in children with cleft palate (mOMEnt): a feasibility study and economic evaluation

Iain Bruce
,
Nicola Harman
,
Paula Williamson
,
Stephanie Tierney
,
Peter Callery
,
Syed Mohiuddin
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 68
  • Published:
    1 September 2015

Extended Research Article

The impact of the National Institute for Health Research Health Technology Assessment programme, 2003 13: a multimethod evaluation

Susan Guthrie
,
Teresa Bienkowska-Gibbs
,
Catriona Manville
,
Alexandra Pollitt
,
Anne Kirtley
,
Steven Wooding
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 67
  • Published:
    1 September 2015

Extended Research Article

Saline in Acute Bronchiolitis RCT and Economic evaluation: hypertonic saline in acute bronchiolitis - randomised controlled trial and systematic review

Mark L Everard
,
Daniel Hind
,
Kelechi Ugonna
,
Jennifer Freeman
,
Mike Bradburn
,
Simon Dixon
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 66
  • Published:
    24 August 2015

Extended Research Article

Dual-chamber pacemakers for treating symptomatic bradycardia due to sick sinus syndrome without atrioventricular block: a systematic review and economic evaluation

Steven J Edwards
,
Charlotta Karner
,
Nicola Trevor
,
Victoria Wakefield
,
Fatima Salih
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 65
  • Published:
    24 August 2015

Extended Research Article

Individual cognitive stimulation therapy for dementia: a clinical effectiveness and cost-effectiveness pragmatic, multicentre, randomised controlled trial

Vasiliki Orgeta
,
Phuong Leung
,
Lauren Yates
,
Sujin Kang
,
Zoe Hoare
,
Catherine Henderson
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 64
  • Published:
    20 August 2015

Extended Research Article

Use of drug therapy in the management of symptomatic ureteric stones in hospitalised adults: a multicentre, placebo-controlled, randomised controlled trial and cost-effectiveness analysis of a calcium channel blocker (nifedipine) and an alpha-blocker (tamsulosin) (the SUSPEND trial)

Robert Pickard
,
Kathryn Starr
,
Graeme MacLennan
,
Mary Kilonzo
,
Thomas Lam
,
Ruth Thomas
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 63
  • Published:
    5 August 2015

Extended Research Article

Diagnostic accuracy of the Thessaly test, standardised clinical history and other clinical examination tests (Apley's, McMurray's and joint line tenderness) for meniscal tears in comparison with magnetic resonance imaging diagnosis

Mark Blyth
,
Iain Anthony
,
Bernard Francq
,
Katriona Brooksbank
,
Paul Downie
,
Andrew Powell
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 62
  • Published:
    5 August 2015

Extended Research Article

A randomised controlled trial of Outpatient versus inpatient Polyp Treatment (OPT) for abnormal uterine bleeding

T Justin Clark
,
Lee J Middleton
,
Natalie AM Cooper
,
Lavanya Diwakar
,
Elaine Denny
,
Paul Smith
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 61
  • Published:
    30 July 2015

Extended Research Article

A systematic review and economic evaluation of exercise referral schemes in primary care: A short report

Fiona Campbell
,
Mike Holmes
,
Emma Everson-Hock
,
Sarah Davis
,
Helen Buckley Woods
,
Nana Anokye
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 60
  • Published:
    29 July 2015

Extended Research Article

Effectiveness and economic evaluation of self-help educational materials for the prevention of smoking relapse: randomised controlled trial

Annie Blyth
,
Vivienne Maskrey
,
Caitlin Notley
,
Garry R Barton
,
Tracey J Brown
,
Paul Aveyard
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 59
  • Published:
    28 July 2015

Extended Research Article

Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: a systematic review and cost-effectiveness analysis

Penny Whiting
,
Maiwenn Al
,
Marie Westwood
,
Isaac Corro Ramos
,
Steve Ryder
,
Nigel Armstrong
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 58
  • Published:
    28 July 2015

Extended Research Article

A systematic review and individual patient data meta-analysis of prognostic factors for foot ulceration in people with diabetes: the international research collaboration for the prediction of diabetic foot ulcerations (PODUS)

Fay Crawford
,
Genevieve Cezard
,
Francesca M Chappell
,
Gordon D Murray
,
Jacqueline F Price
,
Aziz Sheikh
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 57
  • Published:
    28 July 2015

Extended Research Article

Psychological and psychosocial interventions for cannabis cessation in adults: a systematic review short report

Katy Cooper
,
Robin Chatters
,
Eva Kaltenthaler
,
Ruth Wong
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 56
  • Published:
    22 July 2015

Extended Research Article

ACTIvATeS: ACTive Treatment for Idiopathic AdolescenT Scoliosis - A feasibility study

Mark A Williams
,
Peter J Heine
,
Esther M Williamson
,
Francine Toye
,
Melina Dritsaki
,
Stavros Petrou
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 55
  • Published:
    22 July 2015

Extended Research Article

Computed tomographic colonography compared with colonoscopy or barium enema for diagnosis of colorectal cancer in older symptomatic patients: two multicentre randomised trials with economic evaluation (the SIGGAR trials)

Steve Halligan
,
Edward Dadswell
,
Kate Wooldrage
,
Jane Wardle
,
Christian von Wagner
,
Richard Lilford
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 54
  • Published:
    22 July 2015

Extended Research Article

Initiating change locally in bullying and aggression through the school environment (INCLUSIVE): pilot randomised controlled trial

Chris Bonell
,
Adam Fletcher
,
Natasha Fitzgerald-Yau
,
Daniel Hale
,
Elizabeth Allen
,
Diana Elbourne
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 53
  • Published:
    20 July 2015

Extended Research Article

Clinical effectiveness and cost-effectiveness of parenting interventions for children with severe attachment problems: a systematic review and meta-analysis

Barry Wright
,
Melissa Barry
,
Ellen Hughes
,
Dominic Trépel
,
Shehzad Ali
,
Victoria Allgar
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 52
  • Published:
    16 July 2015

Extended Research Article

Pan-retinal photocoagulation and other forms of laser treatment and drug therapies for non-proliferative diabetic retinopathy: systematic review and economic evaluation

Pamela Royle
,
Hema Mistry
,
Peter Auguste
,
Deepson Shyangdan
,
Karoline Freeman
,
Noemi Lois
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 51
  • Published:
    15 July 2015

Extended Research Article

A feasibility randomised controlled trial of a motivational interviewing-based intervention for weight loss maintenance in adults

Sharon A Simpson
,
Rachel McNamara
,
Christine Shaw
,
Mark Kelson
,
Yvonne Moriarty
,
Elizabeth Randell
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 50
  • Published:
    14 July 2015

Extended Research Article

Ablative therapy for people with localised prostate cancer: a systematic review and economic evaluation

Craig R Ramsay
,
Temitope E Adewuyi
,
Joanne Gray
,
Jenni Hislop
,
Mark DF Shirley
,
Shalmini Jayakody
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 49
  • Published:
    2 July 2015

Extended Research Article

The clinical and cost-effectiveness of point-of-care tests (CoaguChek system, INRatio2 PT/INR monitor and ProTime Microcoagulation system) for the self-monitoring of the coagulation status of people receiving long-term vitamin K antagonist therapy compared with standard UK practice: systematic review and economic evaluation

Pawana Sharma
,
Graham Scotland
,
Moira Cruickshank
,
Emma Tassie
,
Cynthia Fraser
,
Chris Burton
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 48
  • Published:
    2 July 2015

Extended Research Article

Erlotinib and gefitinib for treating non-small cell lung cancer that has progressed following prior chemotherapy (review of NICE technology appraisals 162 and 175): a systematic review and economic evaluation

Janette Greenhalgh
,
Adrian Bagust
,
Angela Boland
,
Kerry Dwan
,
Sophie Beale
,
Juliet Hockenhull
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 47
  • Published:
    1 July 2015

Extended Research Article

A scoping study to explore the cost-effectiveness of next-generation sequencing compared with traditional genetic testing for the diagnosis of learning disabilities in children

Sophie Beale
,
Diana Sanderson
,
Anna Sanniti
,
Yenal Dundar
,
Angela Boland
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 46
  • Published:
    30 June 2015

Extended Research Article

Non-pharmacological interventions for attention-deficit/hyperactivity disorder (ADHD)delivered in school settings: systematic reviews of quantitative and qualitative research

Michelle Richardson
,
Darren A Moore
,
Ruth Gwernan-Jones
,
Jo Thompson-Coon
,
Obioha Ukoumunne
,
Morwenna Rogers
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 45
  • Published:
    30 June 2015

Extended Research Article

High-sensitivity troponin assays for the early rule-out or diagnosis of acute myocardial infarction in people with acute chest pain: a systematic review and cost-effectiveness analysis

Marie Westwood
,
Thea van Asselt
,
Bram Ramaekers
,
Penny Whiting
,
Praveen Thokala
,
Manuela Joore
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 44
  • Published:
    30 June 2015

Extended Research Article

The use of measures of obesity in childhood for predicting obesity and the development of obesity-related diseases in adulthood: a systematic review and meta-analysis

Mark Simmonds
,
Jane Burch
,
Alexis Llewellyn
,
Claire Griffiths
,
Huiqin Yang
,
Christopher Owen
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 43
  • Published:
    30 June 2015

Extended Research Article

Pre-hospital non-invasive ventilation for acute respiratory failure: a systematic review and cost-effectiveness evaluation

Abdullah Pandor
,
Praveen Thokala
,
Steve Goodacre
,
Edith Poku
,
John W Stevens
,
Shijie Ren
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 42
  • Published:
    29 June 2015

Extended Research Article

Systematic review of tools to measure outcomes for young children with autism spectrum disorder

Helen McConachie
,
Jeremy R Parr
,
Magdalena Glod
,
Jennifer Hanratty
,
Nuala Livingstone
,
Inalegwu P Oono
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 41
  • Published:
    11 June 2015

Extended Research Article

A multicentre randomised controlled trial and economic evaluation of continuous positive airway pressure for the treatment of obstructive sleep apnoea syndrome in older people: PREDICT

Alison McMillan
,
Daniel J Bratton
,
Rita Faria
,
Magda Laskawiec-Szkonter
,
Susan Griffin
,
Robert J Davies
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 40
  • Published:
    11 June 2015

Extended Research Article

An external pilot study to test the feasibility of a randomised controlled trial comparing eye muscle surgery against active monitoring for childhood intermittent exotropia [X(T)]

Michael Clarke
,
Vanessa Hogan
,
Deborah Buck
,
Jing Shen
,
Christine Powell
,
Chris Speed
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 39
  • Published:
    28 May 2015

Extended Research Article

Treatment of childhood anxiety disorder in the context of maternal anxiety disorder: a randomised controlled trial and economic analysis

Cathy Creswell
,
Susan Cruddace
,
Stephen Gerry
,
Rachel Gitau
,
Emma McIntosh
,
Jill Mollison
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 38
  • Published:
    25 May 2015

Extended Research Article

The prognostic and diagnostic utility of tests of platelet function for the detection of 'aspirin resistance' in patients with established cardiovascular or cerebrovascular disease: A systematic review and economic evaluation

Janine Dretzke
,
Richard D Riley
,
Marie Lordkipanidzé
,
Susan Jowett
,
Jennifer O’Donnell
,
Joie Ensor
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 37
  • Published:
    20 May 2015

Extended Research Article

Supported self-management for patients with moderate to severe chronic obstructive pulmonary disease (COPD): an evidence synthesis and economic analysis

Rachel E Jordan
,
Saimma Majothi
,
Nicola R Heneghan
,
Deirdre B Blissett
,
Richard D Riley
,
Alice J Sitch
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 36
  • Published:
    20 May 2015

Extended Research Article

Clinical diagnostic accuracy of rapid detection of healthcare-associated bloodstream infection in critical care using multi-pathogen real-time polymerase chain reaction (RT-PCR) technology

Geoffrey Warhurst
,
Graham Dunn
,
Paul Chadwick
,
Bronagh Blackwood
,
Daniel McAuley
,
Gavin D Perkins
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 35
  • Published:
    13 May 2015

Extended Research Article

Systematic review, meta-analysis and economic modelling of molecular diagnostic tests for antibiotic resistance in tuberculosis

Francis Drobniewski
,
Mary Cooke
,
Jake Jordan
,
Nicola Casali
,
Tendai Mugwagwa
,
Agnieszka Broda
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 34
  • Published:
    11 May 2015

Extended Research Article

The cost-effectiveness of testing strategies for type 2 diabetes: a modelling study

Mike Gillett
,
Alan Brennan
,
Penny Watson
,
Kamlesh Khunti
,
Melanie Davies
,
Samiul Mostafa
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 33
  • Published:
    11 May 2015

Extended Research Article

Calculating when elective abdominal aortic aneurysm repair improves survival for individual patients: development of the Aneurysm Repair Decision Aid and economic evaluation

Stuart W Grant
,
Matthew Sperrin
,
Eric Carlson
,
Natasha Chinai
,
Dionysios Ntais
,
Matthew Hamilton
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 32
  • Published:
    1 May 2015

Extended Research Article

Interventions designed to improve therapeutic communications between black and minority ethnic people and professionals working in psychiatric services: a systematic review of the evidence for their effectiveness

Kamaldeep Bhui
,
Rabbea’h W Aslam
,
Andrea Palinski
,
Rose McCabe
,
Mark RD Johnson
,
Scott Weich
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 31
  • Published:
    30 April 2015

Extended Research Article

Benefits of Incentives for Breastfeeding and Smoking cessation in pregnancy (BIBS): a mixed-methods study to inform trial design

Heather Morgan
,
Pat Hoddinott
,
Gill Thomson
,
Nicola Crossland
,
Shelley Farrar
,
Deokhee Yi
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 30
  • Published:
    22 April 2015

Extended Research Article

Prasugrel (Efient®) with percutaneous coronary intervention for treating acute coronary syndromes (review of TA182): systematic review and economic analysis

Janette Greenhalgh
,
Adrian Bagust
,
Angela Boland
,
Kerry Dwan
,
Sophie Beale
,
Nigel Fleeman
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 29
  • Published:
    22 April 2015

Extended Research Article

The impact of Cochrane Reviews: a mixed method evaluation of outputs from Cochrane review groups supported by the NIHR

Frances Bunn
,
Daksha Trivedi
,
Phil Alderson
,
Laura Hamilton
,
Alice Martin
,
Emma Pinkney
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 28
  • Published:
    17 April 2015

Extended Research Article

Clinical and cost-effectiveness of foam sclerotherapy, endovenous laser ablation and surgery for varicose veins: results from the CLASS trial

Julie Brittenden
,
Seonaidh C Cotton
,
Andrew Elders
,
Emma Tassie
,
Graham Scotland
,
Craig R Ramsay
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 27
  • Published:
    10 April 2015

Extended Research Article

Clinical effectiveness of elemental nutrition for the maintenance of remission in Crohn's disease: a systematic review and meta-analysis

Alexander Tsertsvadze
,
Tara Gurung
,
Rachel Court
,
Aileen Clarke
,
Paul Sutcliffe
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 26
  • Published:
    1 April 2015

Extended Research Article

Smoking Cessation Intervention for severe Mental Ill Health Trial (SCIMITAR): a pilot randomised control trial of the clinical effectiveness and cost-effectiveness of a bespoke smoking cessation service

Emily Peckham
,
Mei-See Man
,
Natasha Mitchell
,
Jinshuo Li
,
Taeko Becque
,
Sarah Knowles
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 25
  • Published:
    31 March 2015

Extended Research Article

The ProFHER (PROximal Fracture of the Humerus: Evaluation by Randomisation) trial - a pragmatic multicentre randomised controlled trial evaluating the clinical effectiveness and cost-effectiveness of surgical compared with non-surgical treatment for proximal fracture of the humerus in adults

Helen Handoll
,
Stephen Brealey
,
Amar Rangan
,
Ada Keding
,
Belen Corbacho
,
Laura Jefferson
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 24
  • Published:
    31 March 2015

Extended Research Article

A randomised controlled trial and cost-effectiveness analysis of high-frequency oscillatory ventilation against conventional artificial ventilation for adults with acute respiratory distress syndrome. The OSCAR (OSCillation in ARDS) study

Ranjit Lall
,
Patrick Hamilton
,
Duncan Young
,
Claire Hulme
,
Peter Hall
,
Sanjoy Shah
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 23
  • Published:
    24 March 2015

Extended Research Article

A study of cellular counting to determine minimum thresholds for adequacy for liquid-based cervical cytology using a survey and counting protocol

Henry C Kitchener
,
Matthew Gittins
,
Mina Desai
,
John HF Smith
,
Gary Cook
,
Chris Roberts
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 22
  • Published:
    17 March 2015

Extended Research Article

Interventions to treat premature ejaculation: a systematic review short report

Katy Cooper
,
Marrissa Martyn-St James
,
Eva Kaltenthaler
,
Kath Dickinson
,
Anna Cantrell
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 21
  • Published:
    13 March 2015

Extended Research Article

The clinical and cost effectiveness of treatments for idiopathic pulmonary fibrosis: a systematic review and economic evaluation

Emma Loveman
,
Vicky R Copley
,
Jill Colquitt
,
David A Scott
,
Andy Clegg
,
Jeremy Jones
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 20
  • Published:
    12 March 2015

Extended Research Article

Strengthening And stretching for Rheumatoid Arthritis of the Hand (SARAH). A randomised controlled trial and economic evaluation.

Mark A Williams
,
Esther M Williamson
,
Peter J Heine
,
Vivien Nichols
,
Matthew J Glover
,
Melina Dritsaki
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 19
  • Published:
    9 March 2015

Extended Research Article

Art therapy for people with non-psychotic mental disorders

Lesley Uttley
,
Alison Scope
,
Matt Stevenson
,
Andrew Rawdin
,
Elizabeth Taylor Buck
,
Anthea Sutton
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 18
  • Published:
    9 March 2015

Extended Research Article

UK DRAFFT - A Randomised Controlled Trial of Percutaneous Fixation with Kirschner Wires versus Volar Locking-Plate Fixation in the Treatment of Adult Patients with a Dorsally Displaced Fracture of the Distal Radius

Matthew L Costa
,
Juul Achten
,
Caroline Plant
,
Nick R Parsons
,
Amar Rangan
,
Sandy Tubeuf
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 17
  • Published:
    26 February 2015

Extended Research Article

Blinded randomised controlled trial of low-dose Adjuvant Steroids in Adults admitted to hospital with Pandemic influenza (ASAP): a trial 'in hibernation', ready for rapid activation

Wei Shen Lim
,
Clare Brittain
,
Lelia Duley
,
Sheila Edwards
,
Stephen Gordon
,
Alan Montgomery
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 16
  • Published:
    25 February 2015

Extended Research Article

INVESTIGATE-1 Invasive evaluation before surgical treatment of incontinence gives added therapeutic effect?): A mixed methods study to assess the feasibility of a future randomised controlled trial of invasive urodynamic testing prior to surgery for stress urinary incontinence in women

Paul Hilton
,
Natalie Armstrong
,
Catherine Brennand
,
Denise Howel
,
Jing Shen
,
Andrew Bryant
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 15
  • Published:
    25 February 2015

Extended Research Article

Methods for the Estimation of the NICE Cost Effectiveness Threshold

Karl Claxton
,
Steve Martin
,
Marta Soares
,
Nigel Rice
,
Eldon Spackman
,
Sebastian Hinde
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 14
  • Published:
    18 February 2015

Extended Research Article

The clinical effectiveness and cost-effectiveness of telephone triage for managing same-day consultation requests in general practice: a cluster randomised controlled trial comparing general practitioner-led and nurse-led management systems with usual care (the ESTEEM trial)

John L Campbell
,
Emily Fletcher
,
Nicky Britten
,
Colin Green
,
Tim Holt
,
Valerie Lattimer
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 13
  • Published:
    18 February 2015

Extended Research Article

The CUPID trial: a randomised double blind placebo-controlled parallel group multi-centre trial of cannabinoids to slow progression in multiple sclerosis

Susan Ball
,
Jane Vickery
,
Jeremy Hobart
,
Dave Wright
,
Colin Green
,
James Shearer
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 12
  • Published:
    16 February 2015

Extended Research Article

Clinical trial metadata: Defining and extracting metadata on the design, conduct, results and costs of 125 randomised clinical trials funded by the NIHR Health Technology Assessment Programme

James Raftery
,
Amanda Young
,
Louise Stanton
,
Ruairidh Milne
,
Andrew Cook
,
David Turner
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 11
  • Published:
    11 February 2015

Extended Research Article

Total hip replacement and surface replacement for the treatment of pain and disability resulting from end-stage arthritis of the hip (review of technology appraisal guidance 2 and 44): systematic review and economic evaluation

Aileen Clarke
,
Ruth Pulikottil-Jacob
,
Amy Grove
,
Karoline Freeman
,
Hema Mistry
,
Alexander Tsertsvadze
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 10
  • Published:
    3 February 2015

Extended Research Article

Cost-effectiveness of non-invasive methods for assessment and monitoring of liver fibrosis and cirrhosis in patients with chronic liver disease: systematic review and economic evaluation

Catriona Crossan
,
Emmanuel A Tsochatzis
,
Louise Longworth
,
Kurinchi Gurusamy
,
Brian Davidson
,
Manuel Rodríguez-Perálvarez
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 9
  • Published:
    3 February 2015

Extended Research Article

What is the clinical effectiveness and cost-effectiveness of conservative interventions for tendinopathy? An overview of systematic reviews of clinical effectiveness and systematic review of economic evaluations

Linda Long
,
Simon Briscoe
,
Chris Cooper
,
Chris Hyde
,
Louise Crathorne
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 8
  • Published:
    3 February 2015

Extended Research Article

Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for advanced recurrent or refractory ovarian cancer: a systematic review and economic evaluation

Steven J Edwards
,
Samantha Barton
,
Elizabeth Thurgar
,
Nicola Trevor
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 7
  • Published:
    28 January 2015

Extended Research Article

The clinical and cost effectiveness of diversion and aftercare programmes for offenders using Class A drugs: a systematic review and economic evaluation

Karen P Hayhurst
,
Maria Leitner
,
Linda Davies
,
Rachel Flentje
,
Tim Millar
,
Andrew Jones
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 6
  • Published:
    26 January 2015

Extended Research Article

The relative clinical and cost-effectiveness of three contrasting approaches to partner notification for curable sexually transmitted infections (STIs): a cluster randomised trial in primary care

Jackie A Cassell
,
Julie Dodds
,
Claudia Estcourt
,
Carrie Llewellyn
,
Stefania Lanza
,
John Richens
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 5
  • Published:
    26 January 2015

Extended Research Article

TOMMY trial: A comparison of TOMosynthesis with digital MammographY in the UK NHS Breast Screening Programme

Fiona J Gilbert
,
Lorraine Tucker
,
Maureen GC Gillan
,
Paula Willsher
,
Julie Cooke
,
Karen A Duncan
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 4
  • Published:
    19 January 2015

Extended Research Article

The PAndemic INfluenza Triage in the Emergency Department (PAINTED) pilot study

Steve Goodacre
,
Andy Irving
,
Richard Wilson
,
Daniel Beever
,
Kirsty Challen
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 3
  • Published:
    14 January 2015

Extended Research Article

A systematic review and economic evaluation of intraoperative tests (RD-100i OSNA system and Metasin test) for detecting sentinel lymph node metastases in breast cancer

Nicola Huxley
,
Tracey Jones-Hughes
,
Helen Coelho
,
Tristan Snowsill
,
Chris Cooper
,
Yang Meng
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 2
  • Published:
    14 January 2015

Extended Research Article

Screening for psychological and mental health difficulties in young people who offend: a systematic review and decision model

Rachel Richardson
,
Dominic Trépel
,
Amanda Perry
,
Shehzad Ali
,
Steven Duffy
,
Rhian Gabe
et al.
  • Journal:
    Health Technology Assessment Volume: 19, Issue: 1
  • Published:
    12 January 2015